Biased Ligands. Better Drugs.

TRV130 - Mu opioid Biased Ligand for Acute Pain

ProductTargetIndicationLead OpPreclinPhase 1Phase 2Phase 3
TRV027Angiotensin II
type 1 receptor
Acute Heart Failureintravenous
Postoperative Painintravenous
Moderate to Severe Painoral
Delta OpioidDelta-opioid
Parkinson's disease, Pain, Depressionoral
Collaboration with Forest Laboratories

TRV130 is an intravenous G protein biased ligand that targets the mu opioid receptor. Trevena is developing TRV130 for the treatment of moderate to severe acute pain where intravenous therapy is preferred, with a clinical development focus in acute postoperative pain.

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Related Events

  • American Pain Society 33rd Annual Scientific Meeting, Tampa, Florida04/30/2014 - 05/02/2014

    Drs. David Soergel, SVP Clinical Development, Franck Skobieranda, VP Clinical Development, Michael Lark, CSO and Mr. Bob Prachar, SVP Commercial and Corporate Strategy will be attending the American Pain Society 33rd Annual Scientific Meeting from Wednesday April 30 to Saturday May 2, 2014 in Tampa Florida. Dr. Soergel will be presenting a poster entitled “TRV130, a novel biased opioid ligand, elicits increased analgesia with reduced adverse effects compared to morphine in healthy volunteers” on the morning of Friday May 1st, between 8:30 AM and 10:30 AM.

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