Biased Ligands. Better Drugs.

TRV027 - AT1R Biased Ligand for Acute Heart Failure

Target Indication Lead
Optimization
Preclinical
Development
Phase
1
Phase
2
Phase
3
OwnershipCollaborator
TRV027 Angiotensin II type 1 receptor Acute Heart Failure intravenous Actavis
TRV130 Mu-opioid
receptor
Postoperative
Pain
intravenous Trevena Logo
TRV734 Mu-opioid
receptor
Moderate to
Severe Pain
oral Trevena Logo
TRV250 Delta-opioid
receptor
Treatment Refractory Migraine oral Actavis

TRV027 is an intravenous drug for the treatment of acute heart failure (AHF) in combination with standard diuretic therapy, and is currently being investigated in a Phase 2 clinical trial. TRV027 is a β-arrestin biased ligand of the angiotensin II type 1 receptor (AT1R). Forest Laboratories Inc. (NYSE:FRX) has an exclusive option to license TRV027.

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